ea0070oc1.1 | Adrenal and Cardiovascular Endocrinology | ECE2020
Sarkadi Balázs
, Katalin Meszaros
, Krencz Ildiko
, Canu Letizia
, Krokker Lilla
, Zakarias Sara
, Barna Gabor
, Sebestyen Anna
, Papay Judit
, Hujber Zoltan
, Butz Henriett
, Darvasi Otto
, Igaz Peter
, Doczi Judit
, Luconi Michaela
, Chinopoulos Christos
, Patocs Attila
Pheochromocytoma/paragangliomas (Pheo/PGL) are rare neuroendocrine cancers with strong genetic background. Mutations in the SDHB subunit of succinate dehydrogenase (SDH) predispose to malignant disease with limited therapeutic options and poor prognosis. Novel prognostic markers and therapeutic targets are required to decrease the high mortality rate. Glutaminases play a crucial role in the metabolism of SDH impaired tumor cells. By using a host of cellular and molecu...